Background: The transition from student to professional nurse is often overwhelming for newly qualified registered nurses, especially in rural and resource-limited settings. Systemic barriers such as staff shortages, limited resources, and lack of mentorship hinder their ability to gain effective clinical experiences. This gap threatens both the professional development of newly qualified registered nurses and the quality of patient care, justifying the need for this study. Aim: This study aimed to explore how the shortage of resources and functional infrastructure affects the clinical experiences of newly qualified registered nurses. Methods: A descriptive qualitative design was employed, grounded in an interpretivist paradigm. Data were collected through three semi-structured focus group interviews with a purposive sample of 25 NQRNs. A rigorous thematic analysis, following the Braun and Clarke framework, was used to identify, analyze, and report patterns within the data. Results: The analysis revealed a complex interplay of six interconnected themes that define the NQRNs’ experiences: (1) an institutional void of clinical support and mentorship; (2) systemic failures in management and leadership; (3) crippling resource constraints and infrastructure decay; (4) pervasive emotional and psychological distress; (5) a trajectory towards professional burnout; and (6) profound job dissatisfaction and disillusionment. These barriers were found to collectively undermine clinical confidence, compromise patient safety, and threaten nurse retention. Conclusions: NQRNs in the Chris Hani District are navigating a “perfect storm” of systemic failures that hinder their professional development and personal well-being. The findings highlight an urgent need for multi-level interventions, including the implementation of standardized mentorship programs, leadership development for nurse managers, strategic investment in rural health infrastructure, and the establishment of formal mental health support systems. Addressing these foundational issues is paramount to building a resilient nursing workforce and ensuring equitable healthcare delivery.
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